2002/04/13

MCA-Embolism Local Fibrinolytic Intervention Trial


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   It is my pleasure to announce that we have started a national-wide randomized controlled trial for local intra-arterial fibrinolysis of middle cerebral artery embolism.  

   The Japanese Ministry of Health, Welfare, and Labor awarded a 3 year grant for this project. This is the first randomized controlled trial in Japan for fibrinolytic intervention therapy. This intervention therapy has widely been conducted by local physicians in various non-standardized manners lacking of a high level of clinical evidence.  We accordingly struggled to standardize inclusion/exclusion criteria and fibrinolysis procedures so that multiple stroke centers could participate. In this clinical trial, we are highly encouraged to establish the efficacy and effectiveness of local intra-arterial fibrinolysis as a therapeutic strategy in the acute phase of cerebral embolism.

   We have recruited hospitals and stroke centers participating in this trial, and get ready to start the trial early January, 2002. The trial will be ended in December,  2003. The outline of our clinical trial will be documented on this web site.

   We believe this multicenter national-wide trial will provide a better understanding of  fibrinolytic intervention therapy and open a door for challenging brain attack more effectively.

December 1, 2001

Akira Ogawa, M.D. 

Principal Investigator of MELT-Japan

Professor and Chairman
Department of Neurosurgery, Iwate Medical University


Administrative Office

Department of Neurosurgery 
Iwate Medical University

19-1 Uchimaru, Morioka, Iwate 020-8505
 
Email: melt-adm@umin.ac.jp
Phone: +81-19-651-5110 ext. 6609
FAX: +81-19-625-8799

What's New! 

03/05

change of evaluation schedule

02/18

registration process

01/24

Second all-hands meeting

01/09

On-line registration

12/21

report form

12/14

protocol


Responsible MELT Official: Akira Ogawa, M.D.
Site Maintainer: Toshiaki Ueno, M.D.
Comments and Questions
Last Updated: 2002/04/13